MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Identifieur interne : 000D09 ( Main/Exploration ); précédent : 000D08; suivant : 000D10MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Auteurs : Christopher M. Coleman [États-Unis] ; Thiagarajan Venkataraman [États-Unis] ; Ye V. Liu [États-Unis] ; Gregory M. Glenn [États-Unis] ; Gale E. Smith [États-Unis] ; David C. Flyer [États-Unis] ; Matthew B. Frieman [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2017.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Infections à coronavirus (), Modèles animaux de maladie humaine, Souris de lignée BALB C, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vaccins à pseudo-particules virales (administration et posologie), Vaccins à pseudo-particules virales (génétique), Vaccins à pseudo-particules virales (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Vaccins antiviraux, Vaccins synthétiques, Vaccins à pseudo-particules virales.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins synthétiques, Vaccins à pseudo-particules virales.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins synthétiques, Vaccins à pseudo-particules virales.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Infections à coronavirus, Modèles animaux de maladie humaine, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Coronavirus Infections (prevention & control), Disease Models, Animal, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Vaccines, Virus-Like Particle (administration & dosage), Vaccines, Virus-Like Particle (genetics), Vaccines, Virus-Like Particle (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Vaccines, Synthetic, Vaccines, Virus-Like Particle, Viral Vaccines.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, Vaccines, Virus-Like Particle, Viral Vaccines.
- immunology : Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, Vaccines, Virus-Like Particle, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Disease Models, Animal, Mice, Inbred BALB C.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies
Url:
DOI: 10.1016/j.vaccine.2017.02.012
PubMed: 28237499
PubMed Central: 5423355
Affiliations:
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Le document en format XML
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Coleman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Venkataraman, Thiagarajan" sort="Venkataraman, Thiagarajan" uniqKey="Venkataraman T" first="Thiagarajan" last="Venkataraman">Thiagarajan Venkataraman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Liu, Ye V" sort="Liu, Ye V" uniqKey="Liu Y" first="Ye V." last="Liu">Ye V. 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Smith</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Flyer, David C" sort="Flyer, David C" uniqKey="Flyer D" first="David C." last="Flyer">David C. Flyer</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Coronavirus Infections (prevention & control)</term><term>Disease Models, Animal</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Vaccines, Synthetic (administration & dosage)</term><term>Vaccines, Synthetic (genetics)</term><term>Vaccines, Synthetic (immunology)</term><term>Vaccines, Virus-Like Particle (administration & dosage)</term><term>Vaccines, Virus-Like Particle (genetics)</term><term>Vaccines, Virus-Like Particle (immunology)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Infections à coronavirus ()</term><term>Modèles animaux de maladie humaine</term><term>Souris de lignée BALB C</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (immunologie)</term><term>Vaccins à pseudo-particules virales (administration et posologie)</term><term>Vaccins à pseudo-particules virales (génétique)</term><term>Vaccins à pseudo-particules virales (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Vaccines, Synthetic</term><term>Vaccines, Virus-Like Particle</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Synthetic</term><term>Vaccines, Virus-Like Particle</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term><term>Vaccins à pseudo-particules virales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Synthetic</term><term>Vaccines, Virus-Like Particle</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Infections à coronavirus</term><term>Modèles animaux de maladie humaine</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies <italic>in vivo</italic>, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection <italic>in vivo</italic>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. 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Abraham</name></author><author><name sortKey="Bernbaum, J G" uniqKey="Bernbaum J">J.G. Bernbaum</name></author><author><name sortKey="Jahrling, P B" uniqKey="Jahrling P">P.B. Jahrling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lovgren Bengtsson, K" uniqKey="Lovgren Bengtsson K">K. Lovgren Bengtsson</name></author><author><name sortKey="Morein, B" uniqKey="Morein B">B. Morein</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, G" uniqKey="Smith G">G. Smith</name></author><author><name sortKey="Raghunandan, R" uniqKey="Raghunandan R">R. Raghunandan</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Massare, M" uniqKey="Massare M">M. Massare</name></author><author><name sortKey="Nathan, M" uniqKey="Nathan M">M. Nathan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M." last="Coleman">Christopher M. Coleman</name></region><name sortKey="Flyer, David C" sort="Flyer, David C" uniqKey="Flyer D" first="David C." last="Flyer">David C. Flyer</name><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><name sortKey="Glenn, Gregory M" sort="Glenn, Gregory M" uniqKey="Glenn G" first="Gregory M." last="Glenn">Gregory M. Glenn</name><name sortKey="Liu, Ye V" sort="Liu, Ye V" uniqKey="Liu Y" first="Ye V." last="Liu">Ye V. Liu</name><name sortKey="Smith, Gale E" sort="Smith, Gale E" uniqKey="Smith G" first="Gale E." last="Smith">Gale E. Smith</name><name sortKey="Venkataraman, Thiagarajan" sort="Venkataraman, Thiagarajan" uniqKey="Venkataraman T" first="Thiagarajan" last="Venkataraman">Thiagarajan Venkataraman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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